What is Profhilo Structura?
Profhilo Structura is an innovative formulation that contains a higher concentration of HA—specifically, 45 mg/mL. (Compared to 32mg/ml for Normal Profhilo) and unlike traditional HA fillers that rely on chemical cross-linking to enhance stability and longevity, Profhilo Structura utilises a unique approach. It is composed of hybrid cooperative complexes (HCCs) of high and low molecular weight HA, created through a thermally induced process known as NAHYCO® technology. This process does not involve chemical cross-linking, yet it imparts the HA with surprising characteristics, including increased resistance to degradation similar to cross-linked HA fillers.
How does Profhilo Structura Work?
The high concentration of HA in Profhilo Structura, which includes 45 mg of low molecular weight HA and 45 mg of high molecular weight HA per 2 mL, enhances its stability and duration of effect. This unique formulation facilitates a regenerative rather than merely volumising effect. When injected into the lateral cheek fat compartment, Profhilo Structura stimulates adipose tissue regeneration, leading to improved skin firmness and reduction of wrinkles.
Clinical Efficacy and Tolerability
A monocentric study evaluated the efficacy and tolerability of Profhilo Structura in 50 healthy female subjects. The treatment involved injecting the formulation into the lateral cheek fat compartment. The results were compelling:
Facial Volume Loss Scale (FVLS) and Wrinkle Severity Rating Scale (WSRS): Significant improvements were observed in both FVLS and WSRS, as analyzed through 3D photographic documentation four months after the start of the treatment.
Patient Self-Evaluation: All participants reported a marked or very marked improvement in skin firmness and a reduction in both superficial and deep wrinkles.
Long-Term Efficacy: The benefits of Profhilo Structura were more pronounced four months post-treatment compared to earlier assessments, indicating its sustained effect over time.
Comparison to Cross-Linked Dermal Fillers
Traditional dermal fillers rely on chemical cross-linking to achieve the necessary durability and resistance to enzymatic degradation. While effective, these fillers primarily provide a mechanical volumising effect. In contrast, Profhilo Structura’s HCCs, although not chemically cross-linked, demonstrate enhanced resistance to degradation due to the high concentration of HA. This results in a longer-lasting effect, similar to that of cross-linked fillers.
However, the true innovation of Profhilo Structura lies in its regenerative properties. Instead of simply adding volume, it promotes the restoration of adipose tissue in the lateral cheeks, as evidenced by ultrasound evaluations of skin thickness and fat hyperechoic areas. This regenerative effect leads to natural-looking volume restoration and a "lipo-lifting" effect, enhancing overall facial aesthetics.
Conclusion
Profhilo Structura represents a significant advancement in aesthetic treatments, it is a novel alternative to traditional cross-linked dermal fillers. Its ability to improve tissue firmness and reduce wrinkles through a regenerative approach, combined with its prolonged duration of effect, makes it an attractive option for those seeking natural and long-lasting facial rejuvenation.
